Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health
Authors' conclusion
Medium-term increased water intake largely expands the resting volume and output of the LV while reducing arterial elastance and cardiac afterload, without altering intravascular volumes, cardiac or aerobic capacities. With the addition of HUS, relaxation properties of the resting LV are further improved.
Study context
- Population
- Healthy adultsage 42 ± 18 years, 51% female
- Participants
- 35 adults
- Comparison
- IFI or IFI + HUS for 3 months
Methodological detailsmatched by sex, age, body composition, physical activity, and cardiorespiratory fitness
- Matched by sex, age, body composition, physical activity, and cardiorespiratory fitness
Primary result
As reported in the abstract
Intravascular volumes (plasma and red blood cell volumes) · 3 months
- Not modified by IFI or IFI + HUS
Further findings
Resting left ventricular (LV) end-diastolic volume, stroke volume (SV) and systolic emptying rate · 3 months
- Increased after IFI and IFI + HUS
- P ≤ 0.007
- Effects on SV and systolic emptying rate larger in IFI + HUS vs IFI
- P ≤ 0.037
Arterial elastance and cardiac afterload · 3 months
- Similarly reduced by IFI and IFI + HUS
- P ≤ 0.006
Resting LV diastolic filling rate and lateral wall e' velocity · 3 months
- Only increased after IFI + HUS
- P ≤ 0.031
Exercise SV, cardiac output and peak VO2 · 3 months
- Not altered by IFI or IFI + HUS
Original publication
Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health. JACC Adv. Published 8 January 2025. doi:10.
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