Coronary disease & ACSCohort study
Mental disorders, mortality following myocardial infarction, and the impact of the COVID-19 pandemic in England: a cohort study
- cohort study
Authors' conclusion
Our findings highlight the increased risk of post-MI mortality in people with mental disorders. Improved implementation of acute cardiac care standards may help to close the gap.
Study context
- Population
- People with MI in England (November 2019-February 2023) from the Myocardial Ischaemia National Audit ProgrammeNon-STEMI (NSTEMI) 131,075 · ST-elevation MI (STEMI) 79,045
- Exposure
- people with each of schizophrenia, bipolar disorder, or depression (of any severity) vs. those without these disorders
Main finding
As reported in the abstract
30-day mortality, NSTEMI · 30 days
Each group vs without these disordersOdds ratio (95% CI)
schizophrenia
1.73(1.20–2.49)
depression
1.17(1.08–1.26)
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| 30-day mortality, STEMI · 30 days — schizophrenia vs without these disorders · higher mortality | 1.61 (1.09–2.37) | |
| 30-day mortality, STEMI · 30 days — bipolar disorder vs without these disorders · higher mortality | 1.68 (1.08–2.59) | |
| 30-day mortality, STEMI · 30 days — depression vs without these disorders · higher mortality | 1.10 (1.01–1.20) | |
| 0.20.5125Odds ratio (log scale) |
One-year mortality, NSTEMI and STEMI
- All disorders were associated with higher one-year mortality following NSTEMI and STEMI, with adjustment for care attenuating estimates
Relative mortality disparities by COVID-19 pandemic period
- Relative mortality disparities were generally unaffected by the COVID-19 pandemic
Original publication
Mental disorders, mortality following myocardial infarction, and the impact of the COVID-19 pandemic in England: a cohort study. Eur Heart J Qual Care Clin Outcomes. Published 17 March 2026. doi:10.1093/ehjqcco/qcag044
Summarised from the published abstract; every number is checked against it