Heart failure & cardiomyopathies
Meta-Analysis of Cardiac Magnetic Resonance in Prognosticating Left Ventricular Function in Peripartum Cardiomyopathy
Authors' conclusion
Contrast-enhanced CMR can be utilized as an adjunct examination in post-partum PPCM patients to stratify the risk of poor LV function recovery while conducted at a suitable point in time.
Study context
- Population
- Patients with peripartum cardiomyopathy (mean age 30.6 years; mostly diagnosed after delivery)
- Participants
- 162 patients6 cohort studies
- Comparison
- Late gadolinium enhancement (LGE) and myocardial oedema on cardiac magnetic resonance (CMR) vs absence, for poor left ventricular (LV) function recovery
- Outcome
- Poor LV function recovery
- Follow-up
- ≥6 months
Methodological detailsrandom-effects model, diagnostic-test accuracy meta-analysis
- Random-effects model
- Diagnostic-test accuracy meta-analysis
Pooled result
As reported in the abstract
Relative risk (95% CI)P value
LGECMR at later stage (≥2.8 months)
2.83(1.25–6.40)
P = 0.001Myocardial oedemaT2 mapping; CMR early (<2.8 months)
3.44(1.04–11.34)
P = 0.043Further pooled results
| Outcome | LGE | Myocardial oedema |
|---|---|---|
| Prognostic accuracy for poor LV recovery (diagnostic-test accuracy meta-analysis) · later phase | ||
| Sensitivity | 73% (95% CI, 56-85%) | 12% (95% CI, 2-52%) |
| Specificity | 79% (95% CI, 45-95%) | 68% (95% CI, 39-88%) |
| AUC | 0.78 (95% CI, 0.75-0.82) | 0.40 (95% CI, 0.36-0.44) |
Original publication
Meta-Analysis of Cardiac Magnetic Resonance in Prognosticating Left Ventricular Function in Peripartum Cardiomyopathy. ESC Heart Fail. Published 18 September 2024. doi:10.
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