Acute cardiac care & resuscitation
Metabolic profiles associate with mortality and neurological outcomes in out-of-hospital cardiac arrest patients
Authors' conclusion
This study identifies distinct metabolic profiles associated with neurological recovery after cardiac arrest, suggesting a potential link between metabolic states and outcomes that may reflect adaptive brain resilience. These findings highlight the need for further research to explore whether metabolic-targeted interventions could enhance recovery.
Study context
- Population
- Unconscious patients resuscitated from out-of-hospital cardiac arrest (OHCA)consecutive unconscious OHCA patients in the Targeted Temperature Management trial
- Participants
- 156 patients
- Comparison
- Thirty-day mortality and neurological outcomes were compared across these clusters
- Outcome
- Thirty-day mortality
- Follow-up
- 30 days
Methodological detailsconsecutive patients, samples analyzed at hospital admission
- Consecutive patients
- Samples analyzed at hospital admission
Main finding
As reported in the abstract
Further findings
Neurological deaths
- Neurological deaths were lowest in Clusters C
Baseline FFA levels and neurological death
- Baseline FFA levels were independently associated with neurological death
Baseline characteristics
- Median age
- 62 years (IQR 54-68)
- Male
- 87%
Cardiac arrest severity
- Cluster A was linked to greater cardiac arrest severity, including longer time to return of spontaneous circulation (ROSC), increased defibrillations, and higher adrenaline use
Original publication
Metabolic profiles associate with mortality and neurological outcomes in out-of-hospital cardiac arrest patients. Resuscitation. Published 14 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →