Coronary disease & ACSResearch article
Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization
- Emory Cardiovascular Biobank
Authors' conclusion
Air pollution links to metabolic changes that contribute to cardiovascular disease progression and MACE.
Study context
- Population
- Patients undergoing cardiac catheterization in the Emory Cardiovascular Biobank with metabolomic profiling and air pollution dataparticipants with metabolomic profiling, air pollution data, median follow-up 9.8 (IQR: 4.6–12.2) years
- Participants
- 244 patients
- Comparison
- Per IQR higher residential PM2.5, nitrogen oxide (NOx) and CO exposure and major adverse cardiovascular events (MACE)
Main finding
As reported in the abstract
MACE · median follow-up of 9.8 (IQR: 4.6-12.2) years
Subdistribution hazard ratio (95% CI)P value
CO, per IQR higher24% higher risk in MACE
1.24(1.03–1.49)
P = 0.02PM2.5, per IQR higher
1.05(0.86–1.30)
P = 0.62NOx, per IQR higher
1.19(0.99–1.44)
P = 0.068Per IQR higher, as printed
Further findings
Cardiovascular mortality and congestive heart failure
- Both NOx and CO demonstrated associations with cardiovascular mortality
- NOx was associated with congestive heart failure
Pollution-related metabolites
- 1-oleoyl-rac-glycerol was associated with all pollutants and linked to myocardial infarction and stroke
- NOx's effect on MACE was mediated by choline
Original publication
Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization. JACC Adv. doi:10.1016/j.jacadv.2025.102481
Summarised from the published abstract; every number is checked against it