Residential exposome and the risk of coronary obstruction and myocardial ischaemia detected by coronary computed tomography
Authors' conclusion
We found no clear environmental associations with CT-derived coronary obstruction or ischaemia.
Study context
- Population
- Consecutive patients screened by coronary computed tomography angiography (CCTA) for stable chest pain, 2019–2020420 FFRCT analyses
- Participants
- 2,620 patients
- Exposure
- Residential air pollution, noise, and green exposure and CT-derived coronary obstruction and ischaemia
- Outcome
- Obstructive CAD (OCAD, stenosis ≥50%) and abnormal FFRCT (≤80%)
Methodological detailsconsecutive patients, propensity-score adjusted
- Consecutive patients
- Propensity-score adjusted
Main finding
As reported in the abstract
Associations of PM2.5, NO2, major road distance, airport distance, vegetation index with OCAD and abnormal FFRCT
Obstructive coronary artery disease (OCAD)
518
20%
Abnormal FFRCT
276
11%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Airport distance, OCADvs no OCAD (univariable)OCAD risk, per 1 km, univariable | 0.983 (0.974–0.992) | |
| Abnormal FFRCT, high-risk patients (Framingham >20%, subgroup)Per 1 km, after PS adjustment | 0.634 (0.421–0.926) | |
| 0.512Odds ratio (log scale) |
- Airport distance, OCAD vs no OCAD (univariable) — Distance to airport, OCAD vs no OCAD
- 10.841 (7.869-19.022) km vs. 12.297 (8.691-22.843) km, P < 0.001
Airport distance, OCAD vs no OCAD (univariable)
- People living closer to the airport had more cardiovascular (CV) and socio-economic risk factors
Original publication
Residential exposome and the risk of coronary obstruction and myocardial ischaemia detected by coronary computed tomography. Eur J Prev Cardiol. Published 19 February 2025. doi:10.
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