Heart failure & cardiomyopathies
Metabolomics Implicate Eicosanoids in Severe Functional Mitral Regurgitation
Study context
- Population
- Heart failure with reduced ejection fraction (HFrEF) patients on optimal guideline-directed medical therapy
- Participants
- 80 patients
- Exposure
- Severe functional, mitral regurgitation (FMR) vs no or non-severe FMR
- Severe FMRn = 47
- No or non-severe FMRn = 33reference
- Outcome
- Eicosanoid (17) and metabolite (188) levels, severe vs no or non-severe FMR
Methodological detailstargeted plasma metabolomics, untargeted eicosanoid analyses
- Targeted plasma metabolomics
- Untargeted eicosanoid analyses
Main finding
As reported in the abstract
Eicosanoid levels, severe FMR vs no or non-severe FMR (adjusted for age, BMI and sex)
- Metabolites did not differ significantly
- 17 eicosanoids and 188 metabolites analysed
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Metabolomics Implicate Eicosanoids in Severe Functional Mitral Regurgitation. ESC Heart Fail. Published 10 October 2022. doi:10.
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