Valvular & structural heart disease
Suture-based versus plug-based closure for large-bore arterial access: an individual patient-level meta-analysis of randomised trials
Pooled result · Access site-related vascular complicationsResult — go to the resultOdds ratio 0.54 95% CI 0.35–0.82Authors' conclusion
In this patient-level meta-analysis of randomised trials, the ProGlide-based technique for large-bore arterial access was superior to the MANTA-based technique in terms of vascular and bleeding complications.
Study context
- Population
- Patients undergoing transcatheter aortic valve implantation with large-bore arterial access
- Participants
- 722 patients2 RCTs
- Comparison
- Suture-based ProGlide vs plug-based MANTA large-bore vascular closure
- Outcome
- Access site-related vascular complications (VARC-3)
Methodological detailsprespecified subgroup analyses
- Prespecified subgroup analyses
Pooled result
Access site-related vascular complications
Odds ratio
0.54
95% CI 0.35–0.82
ProGlidevs MANTA
OR 0.54 (95% CI 0.35–0.82)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Endovascular stenting or vascular surgery | 0.22 (0.06–0.79) | |
| 0.050.21520Odds ratio (log scale) |
Prespecified subgroups
- No subgroup favouring the plug-based technique
- Clinical outcomes with MANTA better in larger-sized vessels
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Access site-related bleeding events | 0.41 (0.18–0.94) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Suture-based versus plug-based closure for large-bore arterial access: an individual patient-level meta-analysis of randomised trials. EuroIntervention. Published 20 October 2025. doi:10.
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