Valvular & structural heart disease
Mitral Annular Function in Mitral Annular Calcification and Severe Mitral Regurgitation
Authors' conclusion
CCT can quantify mitral annular function and its contribution to LVSV. Moderate-to-severe MAC significantly impairs annular function, reducing its share of LVSV.
Study context
- Population
- Patients with mitral annular calcification (MAC), severe functional mitral regurgitation (FMR) or severe primary mitral regurgitation (PMR), and controls, who underwent cardiac CT (2016–2022)
- Participants
- 200 / 50 / 50 / 50
- Exposure
- MAC vs severe FMR vs severe PMR vs controls
- MACn = 200
- FMRn = 50
- PMRn = 50
- Controlsn = 50reference
- Outcome
- Mitral AVPD and its fractional contribution to left ventricular (LV) stroke volume (SVAVPD%) by cardiac CT
Main finding
As reported in the abstract
| Outcome | FMR | PMR | Controls |
|---|---|---|---|
| ValuesMean, mm | 9.9 | 6.6 | 11.9 |
| SVAVPD% | 45.5% | 46.5% | 45.8% |
- Mean atrioventricular plane displacement (AVPD) differed significantly between controls, PMR and FMR
- P < 0.0001
- SVAVPD% similar across controls, PMR and FMR
- P = 0.94
- Among MAC patients, AVPD decreased with increasing MAC severity
- P < 0.0001
- Grade 3 to 4 MAC: SVAVPD% 26.7% to 28.9% vs 45.5% to 46.5% in non-MAC groups
- P < 0.0001
Observational data: associations, not effects.
Further findings
Independent associations (multivariable linear regression)
- MAC severity independently associated with reduced AVPD and SVAVPD%
- P < 0.0001
Original publication
Mitral Annular Function in Mitral Annular Calcification and Severe Mitral Regurgitation. JACC Adv. Published 17 September 2025. doi:10.
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