Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study
Authors' conclusion
In this nationwide study, MV replacement was associated with a 3.5-fold increased 10-year IE rate, whereas MV repair was not significantly associated with IE, compared with patients at moderate risk of IE.
Study context
- Population
- Patients undergoing isolated mitral valve (MV) replacement or repair and patients at moderate risk of infective endocarditis (IE), Denmark 2000–2020
- Participants
- 1,220 / 3,239 / 209,517
- Exposure
- MV replacement or MV repair vs moderate risk of IE
- MV replacementn = 1,220
- MV repairn = 3,239
- Moderate-riskn = 209,517reference
- Outcome
- First-time infective endocarditis (IE)
- Follow-up
- 10 years
Methodological detailsDanish nationwide registries, multivariable-adjusted
- Danish nationwide registries
- Multivariable-adjusted
Main finding
As reported in the abstract
10-year cumulative incidence of IE
Each group vs moderate-riskHazard ratio (95% CI)
MV replacement
3.52(2.73–4.52)
MV repair
0.76(0.56–1.04)
Observational data: associations, not effects.
Original publication
Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study. Eur Heart J. Published 11 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it