Modifiable risk factors and risk of myocardial infarction in offspring with parental disease
Authors' conclusion
Children of patients with early-onset MI have low absolute risks of MI in the absence of midlife cardiovascular risk factors, especially if the parent also had a low risk factor burden prior to MI.
Study context
- Population
- Offspring and parents from the Framingham Heart Study
- Exposure
- Offspring with parental early-onset myocardial infarction (MI) vs non-predisposed offspring, by shared risk factors
- Outcome
- Absolute 20-year incidence of MI (Aalen-Johansen estimator)
- Follow-up
- 20 years from age 40
Main finding
As reported in the abstract
20-year MI risk at age 40, by cholesterol and hypertension
| Group | High cholesterol | Non-high cholesterol | Hypertension | No hypertension |
|---|---|---|---|---|
| Predisposed | 25.7% (95% CI 11.2-40.2%) | 3.4% (0.5-6.4) | 26.7% (10.8-42.5) | 4.0% (0.9-7.1) |
| Controls | 9.3% (1.5-17.0) | 2.5% (1.1-3.8) | 10.8% (3.2-18.3) | 2.1% (0.8-3.4) |
High cholesterol
Predisposed25.7% (95% CI 11.2-40.2%)
Controls9.3% (1.5-17.0)
Non-high cholesterol
Predisposed3.4% (0.5-6.4)
Controls2.5% (1.1-3.8)
Hypertension
Predisposed26.7% (10.8-42.5)
Controls10.8% (3.2-18.3)
No hypertension
Predisposed4.0% (0.9-7.1)
Controls2.1% (0.8-3.4)
Observational data: associations, not effects.
Further findings
20-year MI risk in offspring without risk factors, by parental risk factors
- 0-1 parental risk factors, age 40
- 0% (0-11.6)
- ≥2 parental risk factors, age 40
- 3.3% (0-9.8)
- 0-1 parental risk factors, age 50
- 2.9% (0-8.4)
- ≥2 parental risk factors, age 50
- 8.5% (0-19.8)
Original publication
Modifiable risk factors and risk of myocardial infarction in offspring with parental disease. Eur J Prev Cardiol. Published 9 May 2024. doi:10.
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