Risk-weighted Apolipoprotein B (apoB) and lipoprotein-associated coronary risk across ethnic groups
- Pooled analysis of cohort studies (Cox estimates pooled by random-effects meta-analysis)
- mutually adjusted Cox estimates
- random-effects meta-analysis within ethnic groups
- separate single-marker models compared discrimination
- prespecified risk-weighted apoB (RW-apoB) equation
- sensitivity analyses: age and sex adjustment, standardized exposures, hard-events, truncated follow-up, CKB-specific logistic regression
+5 more
- mutually adjusted Cox estimates
- random-effects meta-analysis within ethnic groups
- separate single-marker models compared discrimination
- prespecified risk-weighted apoB (RW-apoB) equation
- sensitivity analyses: age and sex adjustment, standardized exposures, hard-events, truncated follow-up, CKB-specific logistic regression
Authors' conclusion
RW-apoB captured lipoprotein-associated risk beyond measured apoB, with discrimination gains statistically demonstrable in the larger White and Chinese groups.
Study context
- Population
- Participants from ARIC, CARDIA, MESA, the Framingham Offspring Study, and China Kadoorie Biobankparticipants with 4,509 coronary events
- Participants
- 40,132 participants
- Comparison
- RW-apoB versus measured apoB for coronary events, across ethnicities
Pooled result
As reported in the abstract
Mean RW-apoB relative to apoB
Mean RW-apoB exceeded apoB in African American and Chinese participants, reflecting higher lipoprotein(a) and triglycerides, respectively
approximately 8 mg/dL
Further pooled results
| Outcome | White | African American | Chinese | Hispanic | C-index | P value |
|---|---|---|---|---|---|---|
| Coronary events per 10 mg/dL RW-apoB, conditional on apoB | HR per 10 mg/dL 1.11 (95% CI 1.05–1.18) | HR per 10 mg/dL 1.11 (95% CI 1.08–1.15) | HR per 10 mg/dL 1.08 (95% CI 1.05–1.11) | HR per 10 mg/dL 1.10 (95% CI 1.01–1.21) | ||
| Discrimination (C-index), RW-apoB versus apoB — RW-apoB vs apoB · White · separate single-marker models | 0.630 versus 0.617 | P < 0.001 | ||||
| Discrimination (C-index), RW-apoB versus apoB — RW-apoB vs apoB · African American · separate single-marker models | 0.606 versus 0.595 | P = 0.085 | ||||
| Discrimination (C-index), RW-apoB versus apoB — RW-apoB vs apoB · Chinese · separate single-marker models | 0.567 versus 0.554 | P = 0.014 | ||||
| Discrimination (C-index), RW-apoB versus apoB — RW-apoB vs apoB · Hispanic · separate single-marker models | 0.540 versus 0.535 | P = 0.756 |
- Coronary events per 10 mg/dL RW-apoB, conditional on apoB: mutually adjusted, pooled within ethnic groups by random-effects meta-analysis
Original publication
Risk-weighted apoB and lipoprotein-associated coronary risk across ethnic groups. Eur J Prev Cardiol. Published 17 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it