Heart failure & cardiomyopathies
Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum
Authors' conclusion
Disease progression was similar in all age groups, and sustained VA also occurred in patients aged >50 years without overt ARVC phenotype at first evaluation.
Study context
- Population
- Patients with early-stage arrhythmogenic right ventricular cardiomyopathy (ARVC) and genotype-positive relatives without overt structural disease and VA at first evaluation313 echocardiographic assessments
- Participants
- 82 patients
- Exposure
- Age <30 years vs 30 to 50 years vs ≥50 years
- Outcome
- Myocardial disease progression by longitudinal biventricular deformation
Methodological detailscomputational modelling (Digital Twins)
- Computational modelling (Digital Twins)
Main finding
As reported in the abstract
Longitudinal strain progression · 6.7 ± 3.3 years of follow-up
LV global longitudinal strain deterioration, similar in all age groups (%-point per year)
0.1
95% CI 0.05–0.15
RV lateral wall longitudinal strain worsening, all age groups (%-point per year)
0.6
95% CI 0.46–0.70
Observational data: associations, not effects.
Further findings
Digital Twin RV lateral wall
- Local differences in myocardial contractility, compliance and activation delay
Safety
- Patients with VA during follow-up
- 6
Original publication
Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. J Am Coll Cardiol. Published 29 August 2023. doi:10.
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