Heart failure & cardiomyopathies
Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis
Authors' conclusion
HFpEF patients experience lower mortality and hospitalization risks than HFrEF patients, even after adjustment for confounders. However, high absolute event rates in HFpEF highlight the need for effective treatment strategies to improve outcomes. PROSPERO registration ID: CRD42024619499.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF)101 studies
- Comparison
- HFpEF vs HFrEF
- Outcome
- All-cause mortality
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
As reported in the abstract
Each group vs HFrEFEstimate (95% CI)P value
HFpEF
RR 0.78(0.69–0.88)
P < 0.001HFpEF
adjusted HR 0.71(0.62–0.80)
P < 0.001Further pooled results
Per 1000 patient-years (PY)
| Outcome | HFpEF | HFrEF | Estimate | P value | |
|---|---|---|---|---|---|
| CV mortality | 73 | 110 | RR 0.64 (95% CI 0.53–0.79) | P < 0.001 | |
| CV mortality | adjusted HR 0.65 (95% CI 0.56–0.75) | P < 0.001 | |||
| HF hospitalizations | 171 | 225 | RR 0.75 (95% CI 0.63–0.91) | P = 0.003 | |
| HF hospitalizations | adjusted HR 0.87 (95% CI 0.78–0.98) | P = 0.02 | |||
| 0.512Ratio (log scale) |
Original publication
Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis. ESC Heart Fail. Published 16 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →