Arrhythmias & electrophysiology
Mortality, Hospitalization, and Cardiac Interventions in Patients With Atrial Fibrillation Aged <65 Years
Authors' conclusion
Patients with AF aged <65 years have significant comorbidity burden and considerable long-term mortality. They are also at a significantly increased risk of hospitalization for heart failure, stroke, and myocardial infarction.
Study context
- Population
- Adults with Atrial Fibrillation (AF) evaluated at University of Pittsburgh Medical Center, January 2010–December 201967,221 with AF
- Participants
- 17,335 vs 918,073
- Exposure
- AF aged <65 years vs contemporary cohort without AF
- AF <65 yearsn = 17,335
- No AFn = 918,073reference
- Outcome
- All-cause mortality
- Follow-up
- Mean >5 years
Methodological detailssingle health system (University of Pittsburgh Medical Center), electronic health records and administrative data
- Single health system (University of Pittsburgh Medical Center)
- Electronic health records and administrative data
Main finding
As reported in the abstract
All-cause mortality, AF <65 years vs comorbidity-adjusted no AF
AF <65 years vs No AFHazard ratio (95% CI)
Men aged <50 years
1.5(1.24–1.79)
Men aged 50-65 years
1.3(1.26–1.43)
Women aged <50 years
2.4(1.82–3.16)
Women aged 50-65 years
1.7(1.6–1.92)
- Deaths among AF <65 years
- 2084
- Mortality, <50 years
- 6.7%
- Mortality, 50-65 years
- 13%
Observational data: associations, not effects.
Further findings
>1 hospitalization for MI, HF and stroke, by age
- MI, <50 years
- 1.3%
- HF, <50 years
- 4.8%
- Stroke, <50 years
- 1.1%
- MI, 50-65 years
- 2.2%
- HF, 50-65 years
- 7.4%
- Stroke, 50-65 years
- 1.1%
Risk factors for mortality in younger patients with AF
- HF, age-related interaction
- P = 0.007
- Hypertension, age-related interaction
- P = 0.013
- Multiple cardiac and noncardiac risk factor (RFs) associated with increased mortality
Original publication
Mortality, Hospitalization, and Cardiac Interventions in Patients With Atrial Fibrillation Aged <65 Years. Circ Arrhythm Electrophysiol. Published 22 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →