Heart failure & cardiomyopathies
Mortality Risk Stratification for Takotsubo Syndrome: Evaluating C-reactive Protein (CRP) Measurement Alongside the InterTAK Prognostic Score
Authors' conclusion
In Takotsubo syndrome, the persistence of inflammatory burden at hospital discharge emerged as an independent predictor of 1 year mortality, augmenting the predictive capacity of the conventional InterTAK prognosis score.
Study context
- Population
- Patients diagnosed with Takotsubo syndrome between 2008 and 2020patients in a multicentre registry
- Participants
- 307 patients
- Predictors
- C-reactive protein (CRP) at discharge in conjunction with the InterTAK prognosis score
- Predicted outcome
- all-cause mortality within 1 year
Methodological detailsmulticentre registry
- Multicentre registry
Model performance
As reported in the abstract
Area under the curve
CRP at discharge, (95% confidence interval 0.68-0.90)
0.81
Optimal threshold
33 mg/L
Sensitivity
65%
Specificity
87%
Further findings
1 year mortality with CRP at discharge ≥ cut-off of 33 mg/L vs below, by InterTAK risk category
- 'intermediate' risk: 25% vs. 1%
- P = 0.008
- 'very high' risk: 40% vs. 10%
- P = 0.02
- Incorporation of CRP at discharge exhibited a significant enhancement in the prediction of 1 year mortality
CRP at discharge by InterTAK quartile
mg/L
- First quartile (25th percentile)
- 9.5
- Second quartile (median)
- 15.8
- Third quartile (75th percentile)
- 25.3
- Fourth quartile (maximum)
- 41.2
- Stepwise increase of CRP at discharge that corresponds to INTERTAK quartiles
Original publication
Mortality Risk Stratification for Takotsubo Syndrome: Evaluating CRP Measurement Alongside the InterTAK Prognostic Score. ESC Heart Fail. Published 16 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →