Heart failure & cardiomyopathies
Value of plasma D-dimer level for prediction of in-hospital mortality in patients presenting with Takotsubo syndrome
Main finding · In-hospital all-cause deathResult — go to the resultOdds ratio 7.06 95% CI 2.90–17.16Authors' conclusion
Elevated D-dimer levels may serve as an additional predictor of increased in-hospital mortality in patients with TTS. Patients with higher D-dimer levels may warrant intensified monitoring and management.
Study context
- Population
- Patients with Takotsubo syndrome (TTS)patients with TTS
- Participants
- 580 patients
- Exposure
- D-dimer level and in-hospital mortality; additive effect of D-dimer level on the InterTAK prognostic risk score
- Outcome
- In-hospital all-cause death
- Follow-up
- In-hospital
Methodological detailsTokyo Cardiovascular Care Unit Network registry
- Tokyo Cardiovascular Care Unit Network registry
Main finding
As reported in the abstract
Odds ratio
7.06
95% CI 2.90–17.16
P < 0.001
D-dimer levels ≥3.5 µg/mL
OR 7.06 (95% CI 2.90–17.16); P < 0.001
- Deaths
- 28 (4.8%)
- Cardiac death
- n = 13, 46.4%
- Non-cardiac death
- n = 15, 53.6%
Observational data: associations, not effects.
Further findings
D-dimer levels on admission · significantly higher in those who died
P < 0.001
Baseline characteristics
- Median age
- 77 years
- Women
- 79.5%
- Emotional trigger
- 174 (30.0%)
- Physical trigger
- 177 (30.5%)
Incremental value of D-dimer added to InterTAK Prognostic Score
- InterTAK Prognostic Score
- 17 (11-24)
- Net reclassification improvement (NRI)
- 1.08, P < 0.001
- Integrated discrimination improvement (IDI)
- 0.05, P < 0.001
Original publication
Value of plasma D-dimer level for prediction of in-hospital mortality in patients presenting with Takotsubo syndrome. Eur Heart J Acute Cardiovasc Care. Published 17 December 2025. doi:10.
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