Cohort study
Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement
- Prospective cohort study
Authors' conclusion
This is the first study to demonstrate that LOY in blood cells is associated with profoundly impaired long-term survival even after successful TAVR.
Study context
- Population
- Men with advanced AS undergoing successful transcatheter aortic valve replacement (TAVR)
- Participants
- 362 men
- Exposure
- LOY in blood cells and mortality after TAVR
- Outcome
- Long-term mortality
- Follow-up
- 3 years
Main finding
As reported in the abstract
Mortality
LOY range
−4% to 83.4%
LOY >10%
48%
Optimal ROC cut-off of LOY to predict mortality
>17%
LOY independent predictor of death during follow-up (multivariate)
P < 0.001
Observational data: associations, not effects.
Further findings
scRNAseq of LOY monocytes
- Pro-fibrotic gene signature: increased TGFβ-associated signalling, TGFβ-inhibiting pathways down-regulated
Original publication
Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement. Eur Heart J. Published 18 March 2023. doi:10.1093/eurheartj/ehad093
Summarised from the published abstract; every number is checked against it