Muesli Intake May Protect Against Coronary Artery Disease: Mendelian Randomization on 13 Dietary Traits
Authors' conclusion
Muesli, a mixture of oats, seeds, nuts, dried fruit, and milk, may causally reduce CAD risk. Circulating levels of acetate, a gut microbiota-derived short-chain fatty acid, could be mediating its cardioprotective effects.
Study context
- Population
- Individuals of European ancestry, UK Biobank and CARDIoGRAMplusC4Dup to 420,531 UK Biobank
- Exposure
- Genetically proxied intake of 13 common dietary traits vs coronary artery disease (CAD) risk
- Outcome
- CAD risk per genetically proxied muesli intake
Methodological detailscross-sectional genetic and dietary data, fixed effect inverse-variance weighted regression (primary), sensitivity analyses: weighted median, MR-Egger, MR-PRESSO
- Cross-sectional genetic and dietary data
- Fixed effect inverse-variance weighted regression (primary)
- Sensitivity analyses: weighted median, MR-Egger, MR-PRESSO
Main finding
As reported in the abstract
Muesli intake, OR for CAD
0.74
95% CI 0.65–0.84P = 5.385 × 10-4
Observational data: associations, not effects.
Further findings
Plasma acetate as potential mediator (higher levels)
- Higher plasma acetate, OR
- 0.03 (95% CI 0.01-0.12; P = 1.15 × 10-4)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Muesli Intake May Protect Against Coronary Artery Disease: Mendelian Randomization on 13 Dietary Traits. JACC Adv. Published 6 March 2024. doi:10.
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