Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial
Authors' conclusion
The current study showed an independent relationship between specific lipid species determined by a plasma lipidomic analysis and non-calcified coronary plaque progression assessed by a serial, quantitative coronary CTA analysis.
Study context
- Population
- Patients with suspected coronary artery disease (CAD) undergoing baseline coronary computed tomography angiography (CTA), with CTA re-evaluation at follow-upof 202 in main study
- Participants
- 154 patients
- Primary endpoint
- Association between plasma lipid species and coronary plaque changes by composition on quantitative serial coronary CTA
- Follow-up
- Inter-scan period 6.39 ± 1.17 years
Methodological detailsmulticentre (7 EU centres), serial coronary CTA, core laboratory blinded to clinical data
- Multicentre (7 EU centres)
- Serial coronary CTA
- Core laboratory blinded to clinical data
Primary result
As reported in the abstract
- Cholesteryl ester(20:3) positively related to non-calcified plaque progression (adjusted)
- Bonferroni-adjusted P=0.005
- Sphingomyelin (SM)(40:3) positively related to non-calcified plaque progression (adjusted)
- Bonferroni-adjusted P=0.016
- SM(41:1) positively related to non-calcified plaque progression (adjusted)
- Bonferroni-adjusted P=0.004
Original publication
Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial. Eur Heart J Cardiovasc Imaging. Published 6 March 2024. doi:10.
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