Heart failure & cardiomyopathies
Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis
Authors' conclusion
There is a wide variation in cardiac phenotype between different amyloidosis types across different degrees of cardiac uptake.
Study context
- Population
- Patients with systemic amyloidosis characterised by biomarkers, echocardiography, cardiac magnetic resonance (CMR) and bone scintigraphy
- Participants
- 296 patients
- Exposure
- Cardiac phenotype by degree of cardiac uptake on bone scintigraphy across amyloidosis types
- ALn = 117
- ATTRn = 165
- AApoAIn = 7
- AApoAIVn = 7
- Outcome
- Cardiac phenotype by grade of myocardial radiotracer uptake
Main finding
As reported in the abstract
AL grade 1 with characteristic cardiac amyloidosis (CA) (n = 48)
100%
ATTR grade 1 with characteristic CA on CMR: only Ser77Tyr (n = 5)
11.4%
CMR characteristic CA or ECV >0.40 with grade 0 to 1 uptake, sensitivity and specificity for AL (excluding Ser77Tyr, AApoAI, AApoAIV)
100%
Observational data: associations, not effects.
Original publication
Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis. JACC Cardiovasc Imaging. Published 14 September 2022. doi:10.
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