Heart failure & cardiomyopathies
Incident Clinical and Mortality Associations of Myocardial Native T1 in the UK Biobank
Authors' conclusion
This large population study demonstrates the utility of myocardial native T1-mapping for disease discrimination and outcome prediction.
Study context
- Population
- UK Biobank participants with CMR native T1-mapping
- Participants
- 42,308 participants
- Exposure
- Per SD increment of myocardial native T1
- Outcome
- Incident events (incident diseases and mortality) per SD increment of native T1
- Follow-up
- 3.17 ± 1.53 years
Methodological detailspopulation cohort
- Population cohort
Main finding
As reported in the abstract
3.17 ± 1.53 years
Native T1Hazard ratio (95% CI)P value
Incident AF
1.25(1.10–1.43)
P = 9.19 × 10-4Incident HF
1.47(1.31–1.65)
P = 4.79 × 10-11All-cause mortality
1.24(1.12–1.36)
P = 1.51 × 10-5CVD mortality
1.40(1.14–1.73)
P = 0.0014IHD mortality
1.36(1.03–1.80)
P = 0.0310Observational data: associations, not effects.
Further findings
Prevalent conditions, per SD increment of native T1
- Strongest relationship: HF, OR
- 1.41 (95% CI: 1.26-1.57; P = 1.60 × 10-9)
- Strongest relationship: nonischemic cardiomyopathies, OR
- 1.40 (95% CI: 1.16-1.66; P = 2.42 × 10-4)
- Higher myocardial T1 associated with greater odds of prevalent conditions (eg, any CVD, brain disease, HF, nonischemic cardiomyopathies, AF, stroke, DM)
- Corrected P values
Original publication
Incident Clinical and Mortality Associations of Myocardial Native T1 in the UK Biobank. JACC Cardiovasc Imaging. Published 14 September 2022. doi:10.
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