Multi-marker risk assessment in patients hospitalized with COVID-19: Results from the American Heart Association COVID-19 Cardiovascular Disease Registry
Main finding · In-hospital mortality, Q1 to Q5Result — go to the resultOdds ratio 4.67 95% CI 3.05–7.14Authors' conclusion
Among patients hospitalized with COVID-19, cTn and NPs identified patients at high risk for an in-hospital adverse cardiovascular outcome, while elevations in D-dimer identified patients at risk for thrombotic complications.
Study context
- Population
- Patients hospitalized with COVID-19 at 122 US hospitals, American Heart Association (AHA) COVID-19 CVD registry, January 2020 to April 2021, with admission biomarker dataof 32,636 registry patients
- Participants
- 26,424 patients
- Exposure
- Admission biomarker quintiles of D-dimer, C-reactive protein (CRP), ferritin, NPs and cardiac troponin (cTn)
- Outcome
- In-hospital death and a CV and thrombotic composite outcome
- Follow-up
- In-hospital
Methodological detailsmulticentre, 122 US hospitals
- Multicentre
- 122 US hospitals
Main finding
In-hospital mortality, Q1 to Q5
Odds ratio
4.67
95% CI 3.05–7.14
Q5vs Q1
OR 4.67 (95% CI 3.05–7.14)
As reported in the abstract
- D-dimer mortality Q1 to Q5
- 14% to 35%
- CRP mortality Q1 to Q5
- 11%-32%
- Ferritin mortality Q1 to Q5
- 11% to 30%
- cTn mortality Q1 to Q5
- 13% to 43%
- NPs mortality Q1 to Q5
- 7% to 35%
Observational data: associations, not effects.
Further findings
Cardiovascular (CV) composite, adjusted
| OR (95% CI) | ||
|---|---|---|
| cTn | 2.68 (2.00–3.59) | |
| NPs | 7.14 (4.92–10.37) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Thrombotic events, D-dimer Q5, adjustedD-dimer | 9.02 (5.36–15.18) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Multi-marker risk assessment in patients hospitalized with COVID-19: Results from the American Heart Association COVID-19 Cardiovascular Disease Registry. Am Heart J. Published 18 January 2023. doi:10.
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