Heart failure & cardiomyopathies
Multi-microRNA Diagnostic Panel for Heart Failure with Preserved Ejection Fraction in Preclinical and Clinical Settings
Authors' conclusion
A panel of four circulating miRNAs was differently expressed in female HFpEF rats and significantly discriminated HFpEF patients from healthy individuals and HFrEF patients. This cross-species and bench-to-bedside approach demonstrates the potential of miRNA-based panels for HFpEF diagnosis.
Study context
- Population
- Female hypertension-induced heart failure with preserved ejection fraction (HFpEF) model (Dahl/Salt Sensitive rats) and human heart failure patients in publicly available datasetsDahl/Salt Sensitive (DSS) rats, high-salt (8%) diet 11 · DSS rats, low-salt (0.3%) diet 15 · GSE53437 control 30 · GSE53437 heart failure with reduced ejection fraction (HFrEF) 41 · GSE53437 HFpEF 19 · GSE104150 female 6 · GSE104150 male 10
- Index test or model
- Panel of four circulating microRNAs (miRNAs) for discrimination of HFpEF patients from healthy individuals and HFrEF patients
- Target condition
- Heart failure with preserved ejection fraction (HFpEF)
Methodological detailscross-species, bench-to-bedside
- Cross-species
- Bench-to-bedside
Performance
As reported in the abstract
- The miRNA panel significantly discriminated HFpEF patients from healthy individuals and HFrEF patients
- GSE53437 dataset
Further findings
HFpEF features in DSS rats
- Diastolic dysfunction and adverse cardiac remodelling with high-salt (8%) vs low-salt (0.3%) diet
Circulating miRNAs in DSS plasma
- rno-let-7b-5p, rno-let-7e-5p, rno-miR-21-5p and rno-miR-140-3p significantly altered
let-7b-5p and miR-21-5p by sex
- Significant downregulation in females compared with males, regardless of health status
- GSE104150 dataset
Original publication
Multi-microRNA Diagnostic Panel for Heart Failure with Preserved Ejection Fraction in Preclinical and Clinical Settings. ESC Heart Fail. Published 2 June 2025. doi:10.
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