Heart failure & cardiomyopathies
Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction
Authors' conclusion
We identified the molecules bufalin and lycorine as drug candidates for therapeutic applications in cardiac fibrosis and diastolic dysfunction.
Study context
- Population
- Primary human cardiac fibroblasts; angiotensin II-mediated murine model of cardiac fibrosis and Dahl salt-sensitive rat modelnatural compounds screened
- Participants
- 480 participants
- Outcome
- Antifibrotic effect in human cardiac fibroblasts and rodent models of cardiac fibrosis
Methodological detailsnatural compound library screening, in vitro and in vivo
- Natural compound library screening
- In vitro and in vivo
Main finding
As reported in the abstract
- Library screening identified substances with antiproliferative effects in human cardiac fibroblasts
- 15
Safety
Toxicology at effective doses
- No change in plasma damage markers or kidney and liver morphology
Original publication
Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation. Published 17 January 2020. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →