Takotsubo Syndrome Before and During the COVID-19 Pandemic in Austria: A Retrospective Cohort Study (TOSCA-19)
Authors' conclusion
Despite the well-known increased psychologic stress during the COVID-19 pandemic, the prevalence of TTS during the COVID-19 pandemic and the short-term clinical outcome in Austria remained unimpacted.
Study context
- Population
- Acute coronary syndrome (ACS) patients (incl. NSTEMI and STEMI) at six Austrian centres6 Austrian centres
- Participants
- 2,572 vs 2,482
- Exposure
- Period 2 vs Period 1
- Period 2n = 2,572
- Period 1n = 2,482reference
- Outcome
- Prevalence of TTS as a percentage of all ACS, and short-term outcome of TTS patients
Methodological detailsmulticentre, propensity-score matched
- Multicentre
- Propensity-score matched
Main finding
As reported in the abstract
Prevalence of TTS among ACS patients
Observational data: associations, not effects.
Further findings
Baseline characteristics of TTS patients
- Baseline characteristics of TTS patients did not change during the COVID-19 pandemic
All-cause in-hospital mortality of TTS patients, before vs during COVID-19 pandemic
- All-cause in-hospital mortality of TTS patients did not change during the COVID-19 pandemic
- χ2 (2) = 0.058, P = 0.810
All-cause in-hospital mortality, matched TTS vs ACS patients during COVID-19 pandemic
- Higher in-hospital mortality in ACS than TTS patients during COVID-19 pandemic
- P = 0.043
- Propensity score matching analysis
Safety
In-hospital complications of TTS patients, before vs during COVID-19 pandemic
- Cardiogenic shock
- 4.6% vs. 4.3%, P = 0.925
- Ventricle thrombus
- 1.1% vs. 1.4%, P = 0.885
- In-hospital bleeding
- 3.4% vs. 1.4%, P = 0.417
- Remained stable
Original publication
Takotsubo Syndrome Before and During the COVID-19 Pandemic in Austria: A Retrospective Cohort Study (TOSCA-19). ESC Heart Fail. Published 6 October 2023. doi:10.
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