Arrhythmias & electrophysiology
Multidimensional prognostic index domain phenotypes identified using latent class analysis and mortality in the European Study of Older Subjects With Atrial Fibrillation (EUROSAF)
Authors' conclusion
In a cohort of older patients with AF, latent class analysis identified 4 MPI domain phenotypes with different risks of mortality. Pending confirmatory studies, the identified subgroups might allow more targeted interventions to improve outcomes in this population.
Study context
- Population
- Older patients with atrial fibrillation (AF) in the European Study of Older Subjects With Atrial Fibrillationpatients with AF
- Participants
- 2,019 patients
- Comparison
- Compared with phenotype 1, 12-month mortality in phenotypes 2, 3 and 4
- Phenotype 1n = 672reference
- Phenotype 2n = 685
- Phenotype 3n = 161
- Phenotype 4n = 501
- Outcome
- Mortality
- Follow-up
- 12-month
Methodological detailsCox regression models
- Cox regression models
Main finding
As reported in the abstract
Each group vs phenotype 1Adjusted hazard ratio (95% CI)
Phenotype 3
4.68(3.41–6.43)
Phenotype 2
1.98(1.53–2.57)
Phenotype 4
1.44(1.07–1.94)
Further findings
Baseline characteristics
- Mean age
- 82.9 years [standard deviation, 7.5]
- Females
- 57%
Original publication
Multidimensional prognostic index domain phenotypes identified using latent class analysis and mortality in the European Study of Older Subjects With Atrial Fibrillation (EUROSAF). Heart Rhythm. Published 12 May 2025. doi:10.
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