Arrhythmias & electrophysiology
Temporal trends in loss of expected lifetime associated with cardiovascular complications following newly diagnosed atrial fibrillation: a Danish nationwide cohort study from 2000 to 2022
Authors' conclusion
Among patients with AF, the loss of expected lifetime after incident ischaemic stroke, HF, and MI improved modestly over the past two decades but not after gastrointestinal or intracranial bleeding.
Study context
- Population
- Patients with atrial fibrillation (AF) developing ischaemic stroke, GI bleeding, intracranial bleeding, heart failure (HF) or myocardial infarction (MI), and matched AF referents, Denmark, 2000–2022matched referents
- Exposure
- AF patients with vs without a CV complication; loss of lifetime 2000–10 vs 2011–22
- Outcome
- Loss of life expectancy (difference in restricted mean survival time between AF patients with and without a complication), compared between periods
Main finding
As reported in the abstract
Loss of life expectancy (difference in restricted mean survival time, AF with vs without complication)
- Ischaemic stroke: loss of lifetime improved (−2.1 vs. −1.8 years)
- difference 4.0 months, 95% CI 2.4-5.6; P < 0.001
- Gastrointestinal bleeding: no evidence of trend (−1.7 vs. −1.8 years)
- difference −0.8 months, 95% CI −2.5 to 0.8; P = 0.32
- Intracranial bleeding: no evidence of trend (−3.3 vs. −3.1 years)
- difference 1.6 months, 95% CI −1.3 to 4.6; P = 0.28
- HF: loss of lifetime improved (−2.1 vs. −1.9 years)
- difference 2.4 months, 95% CI 0.9-3.8; P = 0.001
- MI: loss of lifetime improved (−1.6 vs. −1.1 years)
- difference 5.9 months, 95% CI 3.3-8.5; P < 0.001
Observational data: associations, not effects.
Original publication
Temporal trends in loss of expected lifetime associated with cardiovascular complications following newly diagnosed atrial fibrillation: a Danish nationwide cohort study from 2000 to 2022. Eur Heart J Qual Care Clin Outcomes. Published 12 May 2025. doi:10.
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