Heart failure & cardiomyopathies
Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure
Authors' conclusion
A systems biology approach integrating genomic, transcriptomic, and proteomic data identified 4 major pathways related to mortality.
Study context
- Population
- Patients with HF in the BIOSTAT-CHF studyvalidation cohort n = 1,738
- Participants
- 2,516 patients
- Outcome
- All-cause mortality
- Follow-up
- Median 21 months
Methodological detailsmachine learning (stacked generalization, gradient boosting), independent validation cohort
- Machine learning (stacked generalization, gradient boosting)
- Independent validation cohort
Main finding
As reported in the abstract
Major pathways associated with all-cause mortality
- PI3K/Akt pathway
- MAPK pathway
- Ras signaling pathway
- Epidermal growth factor receptor tyrosine kinase inhibitor resistance
- Validated in an independent cohort of 1,738 patients
Further findings
Deaths during follow-up · median follow-up 21 months
- Patients who died
- 657 (26%)
Original publication
Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure. J Am Coll Cardiol. Published 14 November 2023. doi:10.
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