Multisite Pain and Myocardial Infarction and Stroke: A Prospective Cohort and Mendelian Randomization Analysis
Authors' conclusion
Pain in multiple sites causally increases the risk of MI
Study context
- Population
- UK Biobank participants without myocardial infarction (MI) or stroke at baseline (mean age 56.3 years)
- Participants
- 281,760 participants
- Exposure
- Pain in multiple sites vs fewer or no painful sites
- Outcome
- Incident MI and stroke
- Follow-up
- Median 11.9 years
Methodological detailsUK Biobank, multivariable Cox regression
- UK Biobank
- Multivariable Cox regression
Main finding
As reported in the abstract
Pain 'all over the body'Hazard ratio (95% CI)
MI
1.65(1.32–2.07)
Stroke
1.44(1.13–1.85)
- First MI events
- 4,854
- First stroke events
- 2,827
Observational data: associations, not effects.
Further findings
Chronic pain (≥3 months)
- Similar trends and associations observed
Mendelian randomization
- Supported a causal effect of multisite pain on MI risk, but not vice versa
- No causal association between multisite pain and stroke risk
Original publication
Multisite Pain and Myocardial Infarction and Stroke: A Prospective Cohort and Mendelian Randomization Analysis. JACC Adv. Published 26 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →