Heart failure & cardiomyopathies
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
An erratum to this article was published (Circulation, 13 Jan 2026 ↗)
Authors' conclusion
These findings identify a significant new stem cell signature of cardiometabolic HFpEF and support a role for myeloid maladaptive fatty acid metabolism in the promotion of systemic inflammation and cardiac diastolic dysfunction.
Study context
- Population
- Patients with cardiometabolic heart failure with preserved ejection fraction (HFpEF) and a murine model of high-fat diet and hypertension
Main finding
As reported in the abstract
- Patients with cardiometabolic HFpEF exhibit elevated peripheral blood hematopoietic stem cells
- Phenotype conserved across species in murine model of high-fat diet and hypertension
- Hematopoietic stem cell proliferation coupled to remodeling of the peripheral hematopoietic stem cell niche and expression of macrophage adhesion molecule Vcam1
- Partially inhibited by SGLT2 inhibitors
- Explained by elevated fatty acid metabolism in macrophage mitochondria, which remodeled the Vcam1 promoter to enhance its expression
Original publication
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction. Circulation. Published 12 March 2025. doi:10.
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