Heart failure & cardiomyopathies
Metabolic dysfunction-associated steatotic liver disease and risk of heart failure: a nationwide cohort study
Main finding · Incident HFResult — go to the resultAdjusted hazard ratio 2.62 95% CI 2.39–2.86Authors' conclusion
MASLD is independently associated with incident heart failure beyond traditional CMRFs.
Study context
- Population
- Adults in the Korean National Health Insurance Service screening cohort, 2009–2010, excluding other liver diseases, excessive alcohol use, cancer, cirrhosis or missing data32% with MASLD
- Participants
- 218,605 adults
- Exposure
- MASLD vs no steatotic liver disease and no cardiometabolic risk factor (CMRFs)
- Outcome
- Incident HF
- Follow-up
- Median 9.6 years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Adjusted hazard ratio
2.62
95% CI 2.39–2.86
MASLD vs No steatotic liver disease and CMRFs
adjusted HR 2.62 (95% CI 2.39–2.86)
- Incident HF cases
- 16 340
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| HF risk per additional CMRF | 1.24 (1.22–1.25) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Metabolic dysfunction-associated steatotic liver disease and risk of heart failure: a nationwide cohort study. Heart. Published 15 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →