Heart failure & cardiomyopathies
Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases
Authors' conclusion
DNA damage determines the consequences of human heart failure. Assessment of DNA damage is useful to predict treatment efficacy and prognosis of heart failure patients with various underlying etiologies.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF) of various underlying etiologies undergoing endomyocardial biopsy
- Participants
- 175 patients
- Comparison
- %PAR and %γ-H2A.X as predictors of left ventricular reverse remodeling (LVRR) and outcome
- Outcome
- Left ventricular reverse remodeling (LVRR)
- Follow-up
- 1 year
Performance
As reported in the abstract
Prediction of LVRR
| Test or model | AUC |
|---|---|
| %PAR | 0.867 |
| %γ-H2A.X | 0.855 |
AUC
%PAR0.867
%γ-H2A.X0.855
Secondary outcomes
Composite of CV death, heart transplantation and ventricular assist device implantation (long-term)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher %PAR | 1.63 (1.31–2.01) | P < 0.001 | |
| Higher %γ-H2A.X | 1.48 (1.27–1.72) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Original publication
Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases. JACC Heart Fail. Published 6 November 2023. doi:10.
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