Heart failure & cardiomyopathiesCohort study
Nonischemic or Dual Cardiomyopathy in Patients With Coronary Artery Disease
- Registry study
- consecutive patients
- 4 hospitals
- blinded to clinical outcomes
Authors' conclusion
In patients with CAD referred for clinical cardiovascular magnetic resonance imaging, NICM or dualCM was identified in 1 of every 6 patients and was associated with worse long-term outcomes compared with ICM.
Study context
- Population
- Consecutive patients with obstructive coronary artery disease (CAD) on coronary angiography who underwent contrast-enhanced CMR, 4 hospitals, 2004–2020
- Participants
- 3,023 patients
- Exposure
- CAD+nonischemic cardiomyopathy (NICM) or dualCM vs CAD+ICM
- Outcome
- Composite of:
- All-cause death
- HF hospitalization
- Follow-up
- Median 4.8 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.23
95% CI 1.06–1.43
P = 0.007
CAD+NICM or dualCM vs CAD+ICM
adjusted HR 1.23 (95% CI 1.06–1.43); P = 0.007
- Patients with primary outcome
- 1116
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause death | 1.21 (1.02–1.43) | P = 0.032 | |
| HF hospitalization | 1.37 (1.11–1.69) | P = 0.003 | |
| CV death · did not differ | 1.15 (0.89–1.48) | P = 0.28 | |
| 0.512Hazard ratio (log scale) |
| Outcome | CAD+NICM or dualCM | CAD+ICM | Estimate | P value |
|---|---|---|---|---|
| Prevalence of cardiomyopathy types | Not reported in the abstract | 64.8% |
- Prevalence of cardiomyopathy types — CAD+NICM or dualCM
- 16.9%
- Prevalence of cardiomyopathy types: No cardiomyopathy 18.2%
- Prevalence of cardiomyopathy types: CAD+NICM 9.3%
- Prevalence of cardiomyopathy types: CAD+dualCM 7.7%
Original publication
Nonischemic or Dual Cardiomyopathy in Patients With Coronary Artery Disease. Circulation. Published 6 November 2023. doi:10.1161/circulationaha.123.067032
Summarised from the published abstract; every number is checked against it