Myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction and obstructive coronary disease: outcomes in a Medicare population
An erratum to this article was published (Eur Heart J, 14 Nov 2025 ↗)
Main finding · MACEResult — go to the resultHazard ratio 0.57 95% CI 0.55–0.59Authors' conclusion
This study confirms an unfavourable prognosis in elderly patients with MINOCA undergoing coronary angiography, with one in five patients with MINOCA suffering a major adverse event over 12 months.
Study context
- Population
- Patients ≥65 years with acute myocardial infarction (AMI) undergoing coronary angiography, NCDR CathPCI Registry linked to Medicare claims, July 2009–December 2013
- Participants
- 286,780 AMI admissions
- Exposure
- MINOCA vs MICAD
- MINOCAn = 16,849
- Outcome
- MACE:
- All-cause mortality
- Re-hospitalization for AMI
- HF
- Stroke
- Follow-up
- 12 months
Methodological detailsmulticentre, observational, registry-based (NCDR CathPCI linked to CMS claims)
- Multicentre
- Observational
- Registry-based (NCDR CathPCI linked to CMS claims)
Main finding
MACE
Hazard ratio
0.57
95% CI 0.55–0.59
By group
MINOCAvs MICAD
HR 0.57 (95% CI 0.55–0.59)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality · 12 months
Re-hospitalization for AMI · 12 months
Re-hospitalization for HF · 12 months
Re-hospitalization for stroke · 12 months
- All-cause mortality: P < 0.001
- Re-hospitalization for AMI: P < 0.001
- Re-hospitalization for heart failure (HF): P < 0.001
- Re-hospitalization for stroke: P = 0.128
Adjusted risks of major adverse cardiac events (MACE) components · 12 months
- Pattern similar to MACE
Original publication
Myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction and obstructive coronary disease: outcomes in a Medicare population. Eur Heart J. Published 21 June 2019. doi:10.
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