Proteomic Architecture of Human Coronary and Aortic Atherosclerosis
Authors' conclusion
The human arterial proteome can be viewed as a complex network whose architectural features vary considerably as a function of anatomic location and the presence or absence of atherosclerosis. The data suggest important reductions in mitochondrial protein abundance in early atherosclerosis and also identify a subset of plasma proteins that are highly predictive of angiographically defined coronary disease.
Study context
- Population
- Autopsied young adults (coronary artery and aortic specimens); separate clinical cohort for plasma validation200 arterial specimens
- Participants
- 100 adults
- Comparison
- Atherosclerotic vs normal arterial tissue; coronary vs aortic specimens
- Outcome
- Arterial proteome features in early atherosclerosis
Methodological detailsautopsy specimens, separate clinical validation cohort, Mass spectrometry; convex analysis of mixtures, differential dependent network modeling and bioinformatic analyses
- Autopsy specimens
- Separate clinical validation cohort
- Mass spectrometry; convex analysis of mixtures, differential dependent network modeling and bioinformatic analyses
Main finding
As reported in the abstract
Subset of tissue protein biomarkers measured in plasma predicted anatomically defined coronary atherosclerosis in a separate clinical cohort (AUC)
0.92
0.83–0.96
Original publication
Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. Circulation. Published 19 June 2018. doi:10.
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