Heart failure & cardiomyopathies
Myocardial Inflammation in Cardiac Transthyretin Amyloidosis: Prevalence and Potential Prognostic Implications
Authors' conclusion
Our findings affirm previous evidence that myocardial inflammation is present in approximately one-third of all patients with ATTR-CA. Moreover, we provide first data indicating that myocardial inflammation may be associated with a higher risk of death and heart failure hospitalizations in ATTR-CA.
Study context
- Population
- Patients with ATTR-CA diagnosed by endomyocardial biopsypatients with ATTR-CA (100 wild type, 3 variant) · wild type 100 · variant 3
- Participants
- 103 patients
- Exposure
- Patients with ATTR-CA with and without myocardial inflammation
- With myocardial inflammationn = 33
- Without myocardial inflammationn = 70reference
- Outcome
- All-cause death and a composite end point of all-cause death or heart failure hospitalization
- Follow-up
- Median 18.2 (8.0-31.1) months
Main finding
As reported in the abstract
with myocardial inflammation vs without myocardial inflammationAdjusted hazard ratio (95% CI)P value
All-cause death; adjusted for age and sex
4.72(1.33–16.71)
P = 0.016Composite end point; adjusted for age and sex
2.30(1.04–5.11)
P = 0.041- Overall survival significantly impaired with myocardial inflammation
- P = 0.017
- Composite end point-free survival significantly impaired with myocardial inflammation
- P = 0.014
Observational data: associations, not effects.
Further findings
Prevalence of myocardial inflammation
- Myocardial inflammation prevalent in patients with ATTR-CA
- 32% (n=33/103)
- Among evaluable patients with myocardial inflammation, elevated CD68-positive macrophage counts
- 96% (n=26/27)
- Among evaluable patients with myocardial inflammation, elevated CD3-positive T-cell counts
- 31% (n=9/29)
Original publication
Myocardial Inflammation in Cardiac Transthyretin Amyloidosis: Prevalence and Potential Prognostic Implications. Circ Heart Fail. Published 27 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →