Heart failure & cardiomyopathies
Health-Related Quality of Life Across Heart Failure Categories: Associations with Clinical Characteristics and Outcomes
Authors' conclusion
Most patients were in the two highest EQ 5D-vas categories. Higher NYHA class had the strongest association with lower EQ 5D-vas categories, across all EF categories. Patients in the worst EQ 5D-vas category were at the highest risk of mortality.
Study context
- Population
- Patients with heart failure (HF) with preserved, mildly reduced and reduced ejection fraction (HFpEF, HFmrEF and HFrEF) in the Swedish Heart Failure Registry (SwedeHF; 2000–2021)median age 74 years, 32% female
- Participants
- 40,809 patients
- Exposure
- Associations between patients' characteristics and EQ 5D-vas, and between EQ 5D-vas and outcomes
- Outcome
- Distribution of EQ 5D-vas categories
- Follow-up
- Baseline
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted hazard ratio (95% CI) | |
|---|---|---|
| All-cause death'worst'vs 'best'HFrEF | 1.97 (1.64–2.37) | |
| All-cause death'worst'vs 'best'HFmrEF | 1.77 (1.30–2.40) | |
| All-cause death'worst'vs 'best'HFpEF | 1.43 (1.02–2.00) | |
| 0.512Adjusted hazard ratio (log scale) |
Characteristics associated with lower EQ 5D-vas
- Higher New York Heart Association (NYHA) class strongly associated with lower EQ 5D-vas regardless of ejection fraction (EF) categories, followed by chronic obstructive pulmonary disease, smoking, body mass index, higher heart rate, anaemia, previous stroke, ischaemic heart disease, use of diuretics and living alone
- Higher income, male sex, outpatient status and higher systolic blood pressure inversely associated with lower EQ 5D-vas categories
Original publication
Health-Related Quality of Life Across Heart Failure Categories: Associations with Clinical Characteristics and Outcomes. ESC Heart Fail. Published 27 January 2025. doi:10.
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