Cohort study
Myocardial Injury After Transcatheter Aortic Valve Replacement According to VARC-3 Criteria
- Prospective cohort study
- consecutive patients
Authors' conclusion
About 1 out of 10 patients undergoing TAVR in the contemporary era had PPMI as defined by recent VARC-3 criteria, and baseline factors like female sex and peripheral artery disease determined an increased risk. PPMI had a negative impact on early and late survival.
Study context
- Population
- Consecutive patients undergoing transcatheter aortic valve replacement (TAVR) with a new-generation transcatheter heart valve
- Participants
- 1,394 patients
- Exposure
- PPMI vs no PPMI after TAVR
- PPMIn = 193
- Outcome
- Incidence, predictors and clinical impact (mortality) of PPMI per VARC-3
Main finding
As reported in the abstract
PPMI incidence and mortality
PPMI
14.0%
193 of 193
PPMI vs No PPMIHazard ratio (95% CI)P value
30-day mortality
2.69(1.50–4.82)
P = 0.0011-year all-cause mortality
1.54(1.04–2.27)
P = 0.0321-year CV mortality
3.04(1.68–5.50)
P < 0.001- Female sex and PAD independent predictors of PPMI
- P < 0.01
Observational data: associations, not effects.
Further findings
PPMI by VARC-2 criteria (≥15× troponin)
- No impact on mortality
Original publication
Myocardial Injury After Transcatheter Aortic Valve Replacement According to VARC-3 Criteria. JACC Cardiovasc Interv. Published 22 May 2023. doi:10.1016/j.jcin.2023.03.022
Summarised from the published abstract; every number is checked against it