Heart failure & cardiomyopathies
Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy
Authors' conclusion
The present study reveals unique posttranslational molecular features of the PPCM myocardium, which mediates cellular and metabolic remodeling, and holds promise as potential targets for therapeutic intervention.
Study context
- Population
- LV tissue from end-stage PPCM patients, dilated cardiomyopathy (DCM) patients and nonfailing donors (Sydney Heart Bank)
- Comparison
- End-stage PPCM vs DCM vs nonfailing donors
- PPCMn = 6-7
- DCMn = 5-6
- Nonfailing donorsn = 7-18reference
- Outcome
- LV proteomic and metabolomic profiles
Methodological detailsunbiased quantitative mass spectrometry, Sydney Heart Bank samples
- Unbiased quantitative mass spectrometry
- Sydney Heart Bank samples
Main finding
As reported in the abstract
- SBSPON and TNS3 uniquely downregulated in PPCM
- Elevated homogentisate and deoxycholate and reduced lactate and alanine in PPCM
- PPCM and DCM shared pathways related to inflammation, immune responses and signal transduction
- Thyroid hormone signaling notably reduced in PPCM, with altered PLN and Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) expression
- Enhanced endoplasmic reticulum stress and altered endocytosis pathways in PPCM
Original publication
Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy. Circ Heart Fail. Published 8 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →