Heart failure & cardiomyopathies
Myocardial Inflammation is Associated with Impaired Mitochondrial Oxidative Capacity in Ischaemic Cardiomyopathy
Authors' conclusion
More than every fourth ICM patient with advanced HF displays myocardial inflammation in the range of inflammatory cardiomyopathy associated with reduced mitochondrial oxidative capacity.
Study context
- Population
- Stage D HF undergoing LV assist device implantation or heart transplantation; LV tissue samples obtained during open heart surgery
- Participants
- 81 participants
- Exposure
- Ischaemic cardiomyopathy (ICM) vs dilated cardiomyopathy (DCM)
- ICMn = 44
- DCMn = 37reference
- Outcome
- Mitochondrial oxidative capacity and myocardial inflammation (>14 CD3+ cells/mm²)
Main finding
As reported in the abstract
Values
Relevant inflammation ICM 27% · DCM 6% · P = 0.024
- ICM vs DCM: P = 0.006 — oxidative capacity reduced by 23%
- Number of infiltrating leucocytes correlated with lower oxidative capacity
- r = −0.296, P = 0.019
Observational data: associations, not effects.
Further findings
Maximum ROS production
P = 0.196
Mitochondrial content (CSA)
P = 0.002
Fibrosis
P = 0.002
- Fibrosis — Fibrosis not associated with oxidative capacity
- r = −0.13, P = 0.327
Original publication
Myocardial Inflammation is Associated with Impaired Mitochondrial Oxidative Capacity in Ischaemic Cardiomyopathy. ESC Heart Fail. Published 30 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →