Heart failure & cardiomyopathies
Myocardial tissue characterization by segmental T2 mapping in thalassaemia major: detecting inflammation beyond iron
Authors' conclusion
In TM, T2 mapping does not offer any advantage in terms of sensitivity for MIO assessment but detects subclinical myocardial inflammation.
Study context
- Population
- Thalassaemia major patients enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network102 females
- Participants
- 166 patients
- Exposure
- Segmental T2 mapping vs T2* for detection of myocardial iron overload
- Decreased T2n = 11
- Normal T2n = 74
- Increased T2n = 81
- Outcome
- Global heart T2 categories
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Reduced T2 among patients with decreased global heart T2*
- 11/25 (44.0%)
- Decreased T2 among patients with normal T2*
- 0
Observational data: associations, not effects.
Further findings
Biventricular function
- Comparable amongst the three groups
Late gadolinium enhancement (LGE)
- Significantly more frequent with reduced vs increased global heart T2
Hepatic and pancreatic iron deposition
- Significantly higher with reduced T2 than in the other two groups
Original publication
Myocardial tissue characterization by segmental T2 mapping in thalassaemia major: detecting inflammation beyond iron. Eur Heart J Cardiovasc Imaging. Published 18 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →