Arrhythmias & electrophysiology
N-palmitoyl glycine mediates depression-associated atrial fibrillation via Man1a2-dependent autophagy and NRAP dysregulation
Authors' conclusion
This study demonstrates that N-palmitoyl glycine plays a crucial role in the development of AF in the context of depression.
Study context
- Population
- Rat chronic unpredictable mild stress model of depression; human and rat serum metabolomics
Methodological detailsin vivo and in vitro experiments, chronic unpredictable mild stress rat model of depression
- In vivo and in vitro experiments
- Chronic unpredictable mild stress rat model of depression
Main finding
As reported in the abstract
- Significant increase in atrial fibrillation (AF) inducibility in the chronic unpredictable mild stress model of depression
- N-palmitoyl glycine secreted by the white matter acts as a key factor in depression-associated AF
- These changes lead to intercalated disc rupture, a critical event in AF pathogenesis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
N-palmitoyl glycine mediates depression-associated atrial fibrillation via Man1a2-dependent autophagy and NRAP dysregulation. Europace. Published 24 June 2025. doi:10.
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