Arrhythmias & electrophysiology
Role of interatrial connection ablation in re-entry dynamics: an in silico evaluation
Authors' conclusion
We present the first framework to track re-entrant activity along IACs. We identified IAC-dependent re-entry characteristics that may guide patient stratification and targeted ablation strategies in clinical practice.
Study context
- Population
- Patient-specific biatrial models of atrial fibrillation (AF) (mild and severe AF-related electrical remodelling)
- Participants
- 110 sustained re-entries
- Comparison
- IAC-dependent vs non-IAC-dependent re-entries; in silico IAC ablation
- Outcome
- Proportion of IAC-dependent re-entries and their characteristics (tachycardia cycle length (TCL), phase singularity (PS) clusters in RA body) vs non-IAC-dependent re-entries
Methodological detailsin silico, patient-specific biatrial bilayer models, 6 patient-specific models from CT and MRI; 4 interatrial connections (IACs); Courtemanche ionic model; fibrosis 9.0% (M) to 27.6% (S), 15 IAC ablation strategies tested at 3 timings after circumferential pulmonary vein isolation
- In silico
- Patient-specific biatrial bilayer models
- 6 patient-specific models from CT and MRI; 4 IACs; Courtemanche ionic model; fibrosis 9.0% (M) to 27.6% (S)
- 15 IAC ablation strategies tested at 3 timings after circumferential pulmonary vein isolation
Main finding
TCL
ΔTCL
7.65 ms
P = 0.006
By group
As reported in the abstract
- IAC-dependent re-entries
- 11.8%
Original publication
Role of interatrial connection ablation in re-entry dynamics: an in silico evaluation. Europace. Published 15 June 2026. doi:10.
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