Heart failure & cardiomyopathies
N-Terminal Pro-B-Type Natriuretic Peptide Concentrations, Testing and Associations with Worsening Heart Failure Events
Authors' conclusion
Increased and stable high levels were associated with a WHFE.
Study context
- Population
- Heart failure (HF) patients in the Swedish Heart Failure Registry (SwedeHF) linked with the Stockholm CREAtinine Measurements project, January 2011 to December 201833% with a WHFE
- Participants
- 4,424 patients
- Exposure
- NT-proBNP change patterns vs stable low, and WHFE vs NWHFE
- Outcome
- WHFE (HF hospitalization) by pattern of change in NT-proBNP from 6 months before index to index date
Methodological detailsSwedeHF linked with SCREAM, multivariable logistic regression
- SwedeHF linked with SCREAM
- Multivariable logistic regression
Main finding
As reported in the abstract
WHFE by NT-proBNP change pattern
Each group vs stable lowOdds ratio (95% CI)
Increased
4.27(2.47–7.37)
Stable high
2.48(1.58–3.88)
Observational data: associations, not effects.
Further findings
NT-proBNP testing · 2018
- NT-proBNP testing increased over time
- up to 55% in 2018
- Testing almost two-fold as frequent, and time to testing less than half, in WHFE vs NWHFE
- Independent predictors of testing: WHFE, higher heart rate, diuretic use, preserved EF
NT-proBNP concentration
- Median NT-proBNP (Q1-Q3: 1220-7395) ng/L
- 3070
- Approximately three-fold higher in WHFE vs NWHFE
Original publication
N-Terminal Pro-B-Type Natriuretic Peptide Concentrations, Testing and Associations with Worsening Heart Failure Events. ESC Heart Fail. Published 19 December 2023. doi:10.
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