Heart failure & cardiomyopathies
Reduced Congestion and Improved Response to a Fluid/Sodium Challenge in Chronic Heart Failure Patients After Initiation of Sacubitril/Valsartan: The NATRIUM-HF Study
Authors' conclusion
The initiation of sacubitril/valsartan in HFrEF patients was associated with improvements in natriuresis, diuresis, and weight loss and better clinical adaptation to potentially decongestive stressors.
Study context
- Population
- Patients with stable heart failure with reduced ejection fraction (HFrEF) undergoing an IV fluid/sodium challenge (1 L Ringer, then furosemide)216 completed
- Exposure
- After vs before initiation of sacubitril/valsartan
- Outcome
- Change in natriuresis, diuresis and congestion in response to IV fluid/sodium load
- Follow-up
- 2 and 3 months after initiation
Main finding
As reported in the abstract
2 and 3 months
Mean difference
38.8 ml
P = 0.0040
diuresis; SE-type spread [17.38] as printed
Mean difference
9.6 mmol
P < 0.0001
natriuresis; spread [2.02] as printed
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Natriuresis after furosemideSpread [5.13] as printed | difference 9.8 mmol | P = 0.0167 |
| Body weight · 2 and 3 monthsSacubitril/valsartan vs Baseline · 2 months; [−12.7, 7.4] as printed | difference −0.50 kg | P < 0.0001 |
| Body weight · 2 and 3 monthsSacubitril/valsartan vs Baseline · 3 months; [−15.9, 7.5] as printed | difference −0.75 kg | P < 0.0001 |
Original publication
Reduced Congestion and Improved Response to a Fluid/Sodium Challenge in Chronic Heart Failure Patients After Initiation of Sacubitril/Valsartan: The NATRIUM-HF Study. Eur J Heart Fail. Published 9 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →