Heart failure & cardiomyopathies
The impact of volume and sodium chloride supplementation on diuretic response during decongestion of decompensated heart failure patients
Authors' conclusion
Intravenous fluid replacement during decongestion in patients with AHF was associated with increased net natriuresis and a trend towards higher urine output, with a significant augmentation of diuresis with sodium chloride supplementation.
Study context
- Population
- Patients with acute HF and fluid overload receiving standardized furosemide dosing
- Participants
- 55 patients
- Comparison
- IV fluid vs no fluids during decongestion
- NaCln = 21
- Glucosen = 19
- No fluidsn = 15reference
- Primary endpoint
- Urine volume and natriuresis
- Follow-up
- 6 h after loop diuretic administration
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Cumulative net natriuresis, fluid (n = 40) vs no fluid (n = 15) · 6 h
P = 0.043
Further findings
| Outcome | NaCl | Glucose | No fluids | P value | |
|---|---|---|---|---|---|
| Cumulative net diuresis, fluid vs no fluid · 6 h | Not reported in the abstract | Not reported in the abstract | 1010 (IQR 475–1270) mL | P = 0.078 | NaCl, Glucose: not reported in the abstract |
| Diuretic response by fluid type (absolute and net diuresis; natriuresis) | |||||
| Absolute diuresis | 1980 [1620-3150] mL | 1510 [1075-2175] mL | 1010 [475-1270] mL | ||
| Net diuresis | 1480 [1120-2650] mL | 1010 [575-1675] mL | 1010 [475-1270] mL |
- Diuretic response by fluid type (absolute and net diuresis; natriuresis) — Absolute diuresis, 3-group comparison
- P < .001
- Diuretic response by fluid type (absolute and net diuresis; natriuresis) — Net diuresis, 3-group comparison
- P = .019
- Diuretic response by fluid type (absolute and net diuresis; natriuresis) — Natriuresis difference not significant
- P = .126
- Cumulative net diuresis, fluid vs no fluid: Fluid therapy 1170 (IQR 880–1890) mL
Original publication
The impact of volume and sodium chloride supplementation on diuretic response during decongestion of decompensated heart failure patients. Eur J Heart Fail. Published 12 January 2026. doi:10.
Summarised from the published abstract; every number is checked against it