Heart failure & cardiomyopathies
Natriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial
Authors' conclusion
These findings suggest that natriuresis-guided therapy could be a first step towards personalized treatment of AHF.
Study context
- Population
- Patients with acute HF requiring IV loop diuretics45% female
- Participants
- 310 patients
- Comparison
- Natriuresis-guided diuretic therapy vs standard of care
- Primary endpoint
- Dual: 24 h urinary sodium excretion; time to all-cause mortality or adjudicated HF rehospitalization
- Follow-up
- 180 days (combined endpoint)
Methodological detailspragmatic, open-label
- Pragmatic
- Open-label
Primary result
As reported in the abstract
All-cause mortality or first HF rehospitalization
Hazard ratio
0.92
95% CI 0.62–1.38
P = 0.6980
By group
Natriuresis-guided vs SOC
HR 0.92 (95% CI 0.62–1.38); P = 0.6980
Original publication
Natriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial. Nat Med. Published 28 August 2023. doi:10.
Summarised from the published abstract; every number is checked against it