Natural history of a newly developed calcified nodule: incidence, predictors, and clinical outcomes
Authors' conclusion
New CNs developed in untreated, lipid-containing, severely calcified lesions with a larger angiographic hinge motion (between systole and diastole), compared with lesions without CNs, and were associated with worse clinical outcomes.
Study context
- Population
- Untreated calcified coronary lesions imaged by optical coherence tomography (OCT) at baseline and follow-up
- Participants
- 372 untreated calcified lesions
- Exposure
- Lesions with vs without new calcified nodule
- New CNn = 26
- Outcome
- Incidence of new calcified nodules
- Follow-up
- Median 1.5 (first and third quartiles: 0.7-2.9) years
Methodological detailsserial OCT imaging
- Serial OCT imaging
Main finding
As reported in the abstract
New CN · median 1.5 years
New calcified nodules (CNs) at follow-up
7.0%
26/372
Observational data: associations, not effects.
Further findings
Predictors of new CN development
| OR (95% CI) | P value | ||
|---|---|---|---|
| Attenuated calcium (residual lipid) | 3.38 (1.15–9.98) | P = 0.03 | |
| log10 calcium volume index | 2.76 (1.10–6.95) | P = 0.03 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Predictors of new CN developmentAngiographic Δangle systole–diastole, per 10° | 2.30 (1.25–4.22) | P = 0.01 | |
| Predictors of new CN developmentTime since baseline OCT, per year | 1.36 (1.05–1.75) | P = 0.02 | |
| 0.20.5125Odds ratio (log scale) |
Clinical events (revascularisation and/or MI)
P = 0.04
Original publication
Natural history of a newly developed calcified nodule: incidence, predictors, and clinical outcomes. EuroIntervention. Published 4 November 2024. doi:10.
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