Arrhythmias & electrophysiologyCase-control study
NaV1.5 autoantibodies in Brugada syndrome: pathogenetic implications
- Case-control study
- mechanistic study
- mouse plasma-injection model
Study context
- Population
- Patients with Brugada syndrome and controls
- Participants
- 50 vs 50
- Comparison
- Brugada syndrome (BrS) patients vs controls
- BrSn = 50
- Controlsn = 50reference
- Outcome
- Presence of anti-NaV1.5 autoantibodies (western blot)
Main finding
As reported in the abstract
Anti-NaV1.5 autoantibodies detected
- Diagnostic AUC
- .92
Observational data: associations, not effects.
Original publication
NaV1.5 autoantibodies in Brugada syndrome: pathogenetic implications. Eur Heart J. Published 30 July 2024. doi:10.1093/eurheartj/ehae480
Summarised from the published abstract; every number is checked against it